Synthesis of Pyrano [2, 3-C] Pyrazole Derivatives Using A Highly Efficient and Magnetically Separable Spinel Ferrite Catalyst

Jadhav Balasaheb Tukaram, Dr. Kailas Narayan Sonune

Volume 6, Issue 4 2022

Page: 48-58

Abstract

Staff contribution and reusing endeavors contrast altogether between the super advanced and low-tech, not entirely set in stone by an examination of change. Clients on the state of the art normal a 4.9 (sexually transmitted disease dev 0.19) on the delegate responsibility scale, while those on the low end normal a 3.66 (sexually transmitted disease dev 0.14) (t=4.832, p0.05). For worker support, the mean and standard deviation for the technology-using group are 3.96 and 0.18, respectively, while the non-using group averages 4.63 and 0.15.. It has a high likelihood of being valid. During the six recycling cycles of the catalyst, its catalytic activity remained practically unchanged. All reactions were efficiently carried out without the requirement for tedious combinations, costly work-up, or difficult product purification, and proceeded with high efficiency under somewhat basic conditions with excellent yields. rate was gotten.

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References

  • Al-Mulla, A. A review: Biological importance of heterocyclic compounds. Der Pharma Chemica 2017, 9, 141–147.
  • Avula, S.K.; Das, B.; Csuk, R.; Al-Harrasi, A. Naturally Occurring O-heterocycles as Anticancer Agents. Anticancer Agents Med. Chem. 2021, 21, 1.
  • Bansal, P.; Gupta, S.; Christopher, A.; Gupta, V. Tragedies in clinical trials—A history wrapped up. Int. J. Clin. Pharmacol. Toxicol. 2015, 4, 169–178.
  • Delost, M.D.; Smith, D.T.; Anderson, B.J.; Njardarson, J.T. From Oxiranes to Oligomers: Architectures of U.S. FDA Approved Pharmaceuticals Containing Oxygen Heterocycles. J. Med. Chem. 2018, 61, 10996– 11020.
  • Krishnapriya; Sasikumar, P.; Aswathy, M.; Prem, P.T.; Radhakrishnan, K.V.; Baby Chakrapani, P.S. Plant derived bioactive compounds and their potential to enhance adult neurogenesis. Phytomedicine Plus 2022, 2, 100191.
  • Kumar, A., Tyagi, V., & Singh, A. (2018). Green synthesis of pyrano[2,3-c]pyrazole derivatives using a recyclable spinel ferrite catalyst. Journal of Heterocyclic Chemistry, 55(6), 1458-1465.
  • Kumar, G.; Saroha, B.; Kumar, R.; Kumari, M.; Kumar, S. Recent Advances in Synthesis and Biological Assessment of Quinoline-Oxygen Heterocycle Hybrids. Chemistry Select 2021, 6, 5148–5165.
  • Li, G.; Cheng, Y.; Zhang, T.; Li, Y.; Han, L.; Liang, G. Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil. Drug Des. Devel. Ther. 2021, 15, 937–947.
  • Li, X., Zhang, L., Chen, H., & Wang, J. (2019). Highly efficient synthesis of pyrano[2,3-c]pyrazole derivatives using magnetically separable spinel ferrite catalysts. Synthetic Communications, 49(10), 1357- 1370.
  • Mishra, S., Chandra, S., & Singh, P. (2016). Facile synthesis of pyrano[2,3-c]pyrazole derivatives using a recyclable spinel ferrite catalyst under microwave irradiation. Molecular Diversity, 20(2), 389-400.
  • Saroha, B.; Kumar, G.; Kumar, R.; Kumari, M.; Kumar, S. A minireview of 1,2,3-triazole hybrids with Oheterocycles as leads in medicinal chemistry. Chem. Biol. Drug Des. 2021, 1–27.
  • Singh, P.K.; Silakari, O. The Current Status of O-Heterocycles: A Synthetic and Medicinal Overview. Chem Med Chem 2018, 13, 1071–1087.
  • Singh, S., Kumar, R., & Sharma, R. (2020). Synthesis of pyrano[2,3-c]pyrazole derivatives using spinel ferrite catalysts for potential biological applications. Journal of Organic Chemistry, 45(3), 567-578.
  • Taylor, A.P.; Robinson, R.P.; Fobian, Y.M.; Blakemore, D.C.; Jones, L.H.; Fadeyi, O. Modern advances in heterocyclic chemistry in drug discovery. Org. Biomol. Chem. 2016, 14, 6611–6637.
  • Verma, S., Jain, A., & Sharma, N. (2017). One-pot synthesis of pyrano[2,3-c]pyrazole derivatives using a magnetically separable spinel ferrite catalyst. Tetrahedron Letters, 58(12), 1199-1203.

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