PROTECTION OF RADIATION INDUCED HEMATOPOIETIC INJURY BY PODOPHYLLUM

Mr. ANIRUDH SHARMA

Volume 1, Issue 1 2017

Page: 1-9

Abstract

Hematopoietic system plays very important role in normal function and survival of organisms. A number of reports have validated deleterious effect of radiation on hematopoietic system. The hematopoietic system provides mature functional circulating elements since these have finite life times and cannot reproduce themselves, those lost through the bone marrow does not function if the length of time in which the hematopoietic system does not function too long, the level of vital circulating elements drops too low and the irradiated organism dies. The bone marrow tissues have very rapid turnover times that means constant source of new cells are supplied in order to balance the numbers that are lost. Exposure to a moderate or high dose of total body irradiation (TBI) causes death by Bone marrow (BM) suppression and the most common dose-limiting side effect of conventional cancer therapy using ionizing radiation. The cellular renewal depends upon presence of stem cells. Hematopoietic stem cells (HSC) provide selfrenewal, differentiation capacity and a constant supply of the whole cell spectrum of all hematopoietic lineages throughout our life. HSCs are found in the bone marrow of adults, which includes femurs, hip, ribs, sternum, and other bones. Any process which inhibits or delay the division of stem cells ultimately will cause destruction of this tissue (Loss of proliferative capacity). Markers like Sca 1 have been used for identification of HSC cells and few reports indicated the radiation effect on these Sca 1 HSCs. Many plants and their isolated products have already been shown to protect whole body irradiated mice against hematopoietic injury. Earlier studies at this institute (INMAS) have shown that Podophyllum hexandrum afford protection against radiation induced hematopoietic injury. Hematological parameters like total leukocyte counts, Hemoglobin levels and Colony forming assay have been used to establish hematopoietic protection by P hexandrum. However detailed mechanisms of hematopoietic protection are still unknown.

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